Heme oxygenase-1 expression enhances vascular endothelial resistance to complement- mediated injury through induction of decay-accelerating factor. A role for increased bilirubin and ferritin. Short title: HO-1-induced DAF expression
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Scientific category: Hemostasis, thrombosis and vascular biology IPG and SSH contributed equally to this study Corresponding author: Justin Mason, The Bywaters Center for Vascular Inflammation, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK. Tel: +44-20-8383-1622 Fax: +44-20-383-1640 E-mail: [email protected] Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-04-152934
منابع مشابه
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.
Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprotective action, the regulation of complement activation, mediated via induction ...
متن کاملVASCULAR BIOLOGY Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapoptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprotective action, the regulation of complement activation, mediated via induction o...
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Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
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There is increasing evidence for functional crosstalk between inflammatory and thrombotic pathways in inflammatory vascular diseases such as atherosclerosis and vasculitis. Thus, complement activation on the endothelial cell (EC) surface during inflammation may generate thrombin via the synthesis of tissue factor. We explored the hypothesis that thrombin induces EC expression of the complement-...
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تاریخ انتشار 2008